Fat byproducts like fatty acids and glycerol accelerate aging. The enzyme ADH-1, which breaks down glycerol, shows promise in slowing aging. Interventions such as calorie restriction can extend lifespans, but societal changes are required to accommodate longer life spans.Research suggests that reducing these byproducts, particularly through the enzyme ADH-1, could slow aging.
We hypothesized that elevated ADH-1 activity promotes health in old age by decreasing harmful levels of glycerol. Supporting this hypothesis were. By contrast, animals genetically modified to boost levels of the glycerol-busting enzyme ADH-1 had low glycerol levels and remained lean and healthy with longer lives, even on unrestricted diets.
The simple molecular structure and wealth of research on ADH-1 make it an attractive target for developing drugs that boost its activity. My lab’s long-term goal is to explore how compounds that activate ADH-1 affect the health and longevity of both mice and people.Anti-aging research generates both excitement and debate. On the one hand, the benefits of healthy aging are clear. On the other hand, extending life span through healthier aging will likely introduce new societal challenges.
Whether through ADH-1 or dietary adjustments, the quest for the solution to healthy aging is not just a medical journey but a societal one. Written by Eyleen Jorgelina O’Rourke, Associate Professor of Biology and Cell Biology, University of Virginia.SciTechDaily: Home of the best science and technology news since 1998. Keep up with the latest scitech news via email or social media.
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