octors usually counsel people with diabetes not to abruptly switch or stop taking their regular medications before a surgery. That’s why David Klonoff, an endocrinologist who treats people with diabetes, was surprised when the American Society of Anesthesiologists issued guidancesaying patients should stop taking GLP-1 agonists, the new diabetes and weight loss drugs like Wegovy and Ozempic, before any scheduled surgery.
Say there’s a 45-year-old woman with bladder cancer – would she have fewer complications and better outcomes with radiation treatment or bladder removal? Atropos’ software combs through millions of those records to find similar patients and how they’ve fared and generates a statistical analysis in a matter of days – and, now with recent advances in generative AI – minutes.
The startup is named for one of the three fates in Greek mythology whose scissors have the power to end or extend the lives of mere mortals. The hope is that by generating evidence to help clinicians make better decisions, the company can also help improve outcomes and extend people’s lives. Hyde cofounded Atropos with two experts in healthcare informatics: Nigam Shah, chief data scientist at Stanford Health Care, and pathologist Saurabh Gombar. The trio built software that runs its analyses on each individual data source, in this case, each healthcare institution, and then combines the results in what’s known as a meta-analysis. Using this technique, the company can provide doctors and researchers with retrospective studies based on how real people responded to different therapies.
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