An innovative nanogel delivery system created at the University of Massachusetts Amherst enabled mice with obesity to revert to a normal weight while maintaining a high-fat diet.biomedical engineer has used a nanogel-based carrier designed in his lab to deliver a drug exclusively to the liver of obese mice, effectively reversing their diet-induced disease.
Senior author Thayumanavan, director of the Center for Bioactive Delivery at IALS, explains his team’s findings in a paper published Tuesday, Aug. 29, in the Proceedings of the National Academy of Sciences NEXUS. Ruiling Wu, doing research for her Ph.D. in chemistry in Thayumanavan’s lab and at the Center for Bioactive Delivery, is the paper’s lead author. Wu recently graduated and now works for a pharmaceutical company in Boston.
“We realized we needed to deliver this drug selectively to the liver because if it goes to other places, it could cause complications,” he says. In addition to side effects, taking the drug systemically was expected to dilute its effectiveness, which was confirmed in the study.Thayumanavan and team fed a group of mice a high-fat, high-sugar, high-cholesterol diet for 10 weeks, doubling their weight. A control group of mice were fed a healthy diet.
The obese mice were given the drug daily, packaged inside the nanogel and delivered to the mice via intraperitoneal injection.
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