“The abuse of antibiotics has led to serious bacterial resistance, with about 1.27 million deaths in 2019 due to multidrug-resistant bacterial infections,”co-corresponding author Linlin Li, professor at Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences.
In their study, the authors write that “[r]ecently, the development of chemodynamic therapy offers a potential approach for fighting bacteria and treating infectious diseases, in which those CDT nano agents can catalyze the generation of hydroxyl radicals to destroy bacteria.” “The nano agents only catalyze hydroxyl radical generation at the site of tumor or inflamed tissues, so the therapy is highly specific to reduce off-target toxicity. Bacterial infections also tend to be accompanied by microenvironmental alterations that are favorable for chemodynamic therapy.”
“Metformin is a positively charged small molecule drug with reported anticancer, immunomodulatory and antibacterial effects. We speculated that the integration of metformin with a chemodynamic therapy nano agent would improve the antibacterial effect.” “Compared to previous reports that used metformin as an antibacterial agent alone, excellent antimicrobial effects were achieved in our experiments using lower concentrations of the nanosheets with very short action time,” Li says.
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Source: Nature - 🏆 64. / 68 Read more »