Researchers have identified a biological mechanism involving the molecule KIBRA that explains the long-term stability of memories, shedding light on potential treatments for memory-related disorders.New research identifies the molecule KIBRA as a critical “glue” in stabilizing long-term memories by maintaining synaptic strength, offering insights into memory persistence despite ongoing cellular changes.
“A firmer understanding of how we keep our memories will help guide efforts to illuminate and address memory-related afflictions in the future,” adds Todd Sacktor, a professor at SUNY Downstate Health Sciences University and one of the study’s principal investigators.It’s been long-established that neurons store information in memory as the pattern of strong synapses and weak synapses, which determines the connectivity and function of neural networks.
Their experiments reveal that KIBRA is the “missing link” in long-term memories, serving as a “persistent synaptic tag,” or glue, that sticks to strong synapses and to PKMzeta while also avoiding weak synapses.“During memory formation the synapses involved in the formation are activated—and KIBRA is selectively positioned in these synapses,” explains Sacktor, a professor of physiology, pharmacology, anesthesiology, and neurology at SUNY Downstate.
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