Arc Institute scientists have discovered the bridge recombinase mechanism, a revolutionary tool that enables fully programmablepublication, is the first DNA recombinase that uses a non-codingfor sequence-specific selection of target and donor DNA molecules. This bridge RNA is programmable, allowing the user to specify any desired genomic target sequence and any donor DNA molecule to be inserted.
The bridge recombination system hails from insertion sequence 110 elements, one of countless types of transposable elements – or “jumping genes” – that cut and paste themselves to move within and between microbial genomes. Transposable elements are found across all life forms and have evolved into professional DNA manipulation machines to survive.
Each loop of the bridge RNA is independently programmable, allowing researchers to mix and match any target and donor DNA sequences of interest. This means the system can go far beyond its natural role that inserts the IS110 element itself, instead enabling insertion of any desirable genetic cargo—like a functional copy of a faulty, disease-causing gene—into any genomic location.
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