Vitamin B6 is crucial for brain function, with deficiencies linked to memory issues and depression; however, increasing B6 through supplements alone is insufficient. Researchers at Würzburg University Medicine found that inhibiting the degradation enzyme pyridoxal phosphatase effectively raises cellular B6 levels, offering a potential new treatment avenue for mental and neurodegenerative disorders.
Vitamin B6 plays a crucial role in brain metabolism. Consequently, low levels of vitamin B6 are linked to memory and learning impairments, depressive moods, and clinical depression in various mental disorders. In the elderly, insufficient vitamin B6 is associated with memory decline and dementia. Other participants come from the Rudolf Virchow Center for Integrative and Translational Bioimaging at JMU, the Leibniz-Forschungsinstitut für Molekulare Pharmakologie-FMP Berlin, and the Institute for Clinical Neurobiology at Würzburg University Hospital.
The team also considers it a great success that 7,8-Dihydroxyflavone has been identified as an inhibitor of pyridoxal phosphatase for the first time – after all, this class of enzymes is considered to be particularly challenging for drug development.When will people benefit from this discovery? “It’s too early to say,” explains Marian Brenner, a first author of the study.
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