A new study by the Monell Chemical Senses Center has introduced AF-353, a universal taste blocker that significantly reduces the bitterness of medications, improving compliance among users, especially children and the elderly. This blocker acts by targeting specific receptors that transmit taste information to the brain, without affecting other sensory experiences.Many people, particularly children and the elderly, struggle with swallowing pills.
The team used an inhibitor of P2X2/P2X3 receptors, called AF-353, to block taste-nerve transmission and reduce the bitterness signal caused by medications and other taste compounds. Several blockers of P2X2/P2X3 receptors have been identified, with some tested in clinical trials to treat chronic cough; however, a side effect in these trials was taste disturbance.
The team conducted both human sensory taste testing and mouse behavioral experiments to determine the breadth, strength, and duration of the blocking effects. The results of the human and rodent studies were similar in the breadth and duration of AF-353’s action.
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