A recent study highlights that preemptive use of low-dose aspirin can significantly reduce inflammatory responses due to sleep restriction, showing a decrease in specific inflammatory markers and improved sleep efficiency during recovery. This opens up potential for developing new therapeutic approaches that target inflammatory pathways without the side effects associated with aspirin, potentially complementing existing behavioral therapies for sleep improvement.
“The novelty of this study is that it investigated whether we can pharmacologically reduce the inflammatory consequences of sleep restriction,” said lead author Larissa Engert, who has a doctorate in behavioral physiology and is a postdoctoral fellow in the department of neurology at Beth Israel Deaconess Medical Center and the division of sleep medicine at Harvard Medical School in Boston.
“These findings show that it is possible to blunt inflammatory pathways activated by sleep restriction through preemptive administration of low-dose aspirin. This may foster the development of new therapeutics that specifically target those pathways, and do not exhibit the undesirable side effects associated with aspirin, such as bleeding and stroke.
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