A study reveals that indole-3-propionic acid , a gut-derived molecule, can potentially treat influenza by lowering viral activity and inflammation in mice, with human trials anticipated to confirm these results.
“These results are promising and suggest that IPA may in future be used to help prevent or treat infections by the influenza virus, which causes major epidemics. However, more research is needed to confirm the findings in humans and to understand how IPA works,” said Marco Vinolo, co-last author of the article and a professor at UNICAMP’s Institute of Biology .
The above results followed a series of experiments with mice conducted in France and led by Pasteur-Lille’s François Trottein. The data was later analyzed at UNICAMP using bioinformatics tools, and the results of this analysis in turn inspired further experiments with animals at Pasteur. The other layers of data were obtained by metabolomics, detecting metabolites secreted by the gut microbiota and clinical markers of the disease such as viral load and inflammation.
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