Recent research indicates that maintaining a heart-healthy lifestyle can positively impact biological aging and reduce the risk of cardiovascular diseases and related mortality. The study focused on DNA methylation as a key mediator in this process. By analyzing data from the Framingham Heart Study, the findings highlighted that improvements in lifestyle factors could significantly lower cardiovascular risks, especially for individuals genetically predisposed to accelerated aging.
Researchers examined health data from 5,682 adults who were enrolled in the Framingham Heart Study, an ongoing, large, multigenerational research project aimed at identifying risk factors for heart disease. Using interviews, physical exams, and laboratory tests, all participants were assessed with the, which evaluates 8 heart health lifestyle factors critical to cardiovascular health on a scale from 0 to 100, with 100 being the best.
Overall, about 20% of the association between Life’s Essential 8 scores and cardiovascular outcomes was estimated to be due to the impact of cardiovascular health factors on DNA methylation; in contrast, for participants at higher genetic risk, the association was almost 40%. Participants were followed for an average of 14 years for the children of the original participants and 11 years for the grandchildren.
The four tools to measure DNA methylation-based epigenetic age scores were based on established algorithms for DunedinPACE Score, PhenoAge, DNAmTL, and GrimAge. A fifth tool, GrimAge PGS, assessed genetic tendency toward accelerated biological aging.
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