Researchers from the Institute for the Advanced Study of Human Biology at Kyoto University have made significant strides in human in vitro gametogenesis . They have successfully identified optimal culture conditions that facilitate epigenetic reprogramming with bone morphogenetic protein , a key step towards translating IVG technology into clinical settings for infertility treatments.
According to the World Health Organization, approximately 1 in 6 people are affected by infertility at some point in their life. The American Society for Reproductive Medicine defines infertility as a condition characterized by the inability to achieve a successful pregnancy, based on factors such as medical, sexual, and reproductive history, age, physical findings, and diagnostic testing, or requiring the use of donor gametes to achieve pregnancy.
Remarkably, these hPGCLC-derived mitotic pro-spermatogonia/oogonia not only displayed similarities in gene expression and epigenetic profiles to that of actual hPGC differentiation in our bodies but also underwent extensive amplification . “Our approach enables near-indefinite amplification of mitotic pro-spermatogonia and oogonia in culture and we now also have the ability to store and re-expand these cells as needed,” says Saitou.
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