A study from Scripps Research has made significant advancements in understanding Alzheimer’s disease by employing a novel technique to analyze the electrical activity and protein levels in single neurons. This method, which involves detailed analysis of individual cells, has led to the identification of new molecular targets that could be crucial in developing treatments to slow the disease’s progression.
Previous research by Lipton and others has shown that certain neurons become overactive in the brains of people with Alzheimer’s, sending electrical signals that are stronger or more frequent than usual. Evidence suggests that this overactivity contributes to the cognitive decline associated with Alzheimer’s.
“This approach allows us to connect perturbations of electrical functions to molecular events in neurons, which is an exciting application of proteomics,” says Yates. The proteins were involved in many diverse functions of neurons, including control of electrons in free radicals , energy metabolism, and inflammation. Fifteen of the proteins stood out as having particularly high or low levels in Alzheimer’s neurons, and Lipton’s group is planning follow-up studies on some of these molecules.
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