Researchers at the Institute for Basic Science have identified the anterior cingulate cortex as a key area in the brain responsible for sensory hypersensitivity in autism spectrum disorders. Utilizing a mouse model with a Grin2b gene mutation, the team observed heightened neural activity and connectivity in the ACC. Suppressing this hyperactivity normalized the sensory hypersensitivity, offering new insights into potential treatment targets for ASD-related sensory issues.
A research team led by Director Kim Eunjoon of the Center for Synaptic Brain Dysfunctions and Director Kim Seong-Gi of the Center for Neuroscience Imaging Research at theAutism affects approximately 1 in 36 individuals and is marked by significant challenges in social interaction and communication. Around 90% of autism patients also suffer from abnormal sensory hypersensitivity that deeply affects their daily functioning.
Sensory hypersensitivity in mice with the Grin2b gene mutation found in patients is related to hyperactivity of the anterior cingulate cortex and hyperconnectivity between the ACC and other brain regions. Credit: Institute for Basic Science The hyperactivity of the ACC was also associated with the enhanced functional connectivity between the ACC and other brain areas. It is believed both hyperactivity and the hyperconnectivity of the ACC with various other brain regions are involved with sensory hypersensitivity in Grin2b-mutant mice.
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