New research indicates that unlike flu vaccines, previous COVID-19 immunizations may enhance the efficacy of subsequent vaccines by fostering broad-spectrum neutralizing antibodies, suggesting annual updates could help combat emerging variants and related viruses.responsible continues to circulate, hospitalizing thousands weekly and frequently producing new variants.
Healthcare workers received the first doses of the COVID-19 vaccine in December 2020. A study by researchers at Washington University School of Medicine in St. Louis has found that repeat vaccination with updated versions of the COVID-19 vaccine promotes the development of antibodies that neutralize a wide range of variants of the virus that causes COVID-19, as well as related coronaviruses.
The first question was the strength of the imprinting effect. The researchers measured how many of the participants’ neutralizing antibodies were specific for the original variant, the omicron variant, or both. They found that very few people had developed any antibodies unique to omicron, a pattern indicative of strong imprinting by the initial vaccination. But they also found few antibodies unique to the original variant. The vast majority of neutralizing antibodies cross-reacted with both.
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