A new study from Rockefeller University and UCLA reveals that repetitive practice solidifies neural pathways, making task performance more accurate and automatic. Using advanced imaging techniques, researchers observed how 73,000 cortical neurons in mice stabilized over two weeks of practicing a task, providing insights into learning and memory.
“In this work, we show how working memory—the brain’s ability to hold and process information—improves through practice,” says Vaziri, head of Rockefeller’s Laboratory of Neurology and Biophysics. “We expect that these insights will not only advance our understanding of learning and memory but also have implications for addressing memory-related disorders.
The UCLA researchers turned to Vaziri, who has developed brain imaging techniques that are among the only tools capable of capturing the majority of the mouse cortex in real-time at a high resolution and speed. “This is what we refer to as ‘crystallization,’” Vaziri says. “The findings essentially illustrate that repetitive training not only enhances skill proficiency but also leads to profound changes in the brain’s memory circuits, making performance more accurate and automatic.”
“In the future, we may tackle the role of different neuronal cell types involved in mediating this mechanism, and in particular the interaction of different types of interneurons with excitatory cells,” Vaziri says. “We’re also interested in understanding how learning is implemented and could be transferred into a new context—that is, how the brain could generalize from a learned task to some new unknown problems.
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