Aging clocks, which measure biological age with precision, can deviate from chronological age due to environmental influences like smoking or diet. Researchers at the University of Cologne found that these clocks actually track increasing random cellular changes, suggesting that biological aging could be influenced by stochastic variations in processes like DNA methylation and gene activity.
Scientists David Meyer and Professor Dr Björn Schumacher at CECAD, the Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases of the, have now discovered that aging clocks actually measure the increase in stochastic changes in cells. The study was recently published published in“Aging is triggered when the building blocks in our cells become damaged. Where this damage occurs is for the most part random.
Using the available datasets, the scientists showed that smoking increases the random changes in humans and that ‘anti-aging’ interventions such as lower calorie intake in mice reduce the variation in methylation patterns. They also showed that the stochastic noise is even reversible by means of reprogramming body cells to stem cells. The scientists compared human fibroblasts from the skin that were reprogrammed into stem cells and as a result of the reprogramming are rejuvenating.
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