Researchers at UVA Health discovered that certain antibodies in COVID-19 patients, which behave like enzymes, might be responsible for severe and long-term symptoms, suggesting new targeted treatment approaches.and long COVID. These surprising insights may pave the way for novel treatments targeting the challenging acute impacts of COVID-19, long COVID, and potentially other viruses.
“Some patients with COVID-19 have serious symptoms and we have trouble understanding their cause. We also have a poor understanding of the causes of long COVID,” said Zeichner, a pediatric infectious disease expert at UVA Children’s. “Antibodies that act like enzymes are called ‘abzymes.’ Abzymes are not exact copies of enzymes and so they work differently, sometimes in ways that the original enzyme does not.
Recently, other groups have found that some patients with long COVID have problems with their coagulation systems and with another system called “complement.” Both the coagulation system and the complement system are controlled by enzymes in the body that cut other proteins to activate them.
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