Researchers have identified the gene KDM5B as crucial in regulating learning and memory by conducting experiments with mice. Previously linked to intellectual disabilities and autism, KDM5B’s reduced function was shown to impair memory formation and neuronal connection strengthening in the brain. The study, supported by prominent research institutions and funding bodies, provides a deeper understanding of KDM5B’s role and its potential as a target for new treatments for cognitive disorders.
KDM5B can modify the structure of the genetic material in our cells which determines whether genes necessary for brain development or function are expressed at the correct amount at the right time.ability to modify genetic material has a direct impact on learning and memory. We’ve discovered that the gene has a direct impact on learning and memory – which is distinct from any effect during brain development.
Reference: “The Intellectual Disability Risk Gene Kdm5b Regulates Long-Term Memory Consolidation in the Hippocampus” by Leticia Pérez-Sisqués, Shail U. Bhatt, Rugile Matuleviciute, Talia E. Gileadi, Eniko Kramar, Andrew Graham, Franklin G. Garcia, Ashley Keiser, Dina P. Matheos, James A. Cain, Alan M. Pittman, Laura C. Andreae, Cathy Fernandes, Marcelo A. Wood, K. Peter Giese and M. Albert Basson, 7 May 2024,SciTechDaily: Home of the best science and technology news since 1998.