Recent research highlights the unique role of omental adipose tissue in inhibiting new fat cell formation, offering potential new approaches for targeted obesity treatments and management.
Take, for example, the omentum: a large, apron-like fatty tissue hanging from the stomach that covers organs within the peritoneum, such as the stomach and intestines. It not only stores fat but also plays roles in immune regulation and tissue regeneration. Confocal microscopy fluorescent images of a human omental adipose tissue section , depicting the mesothelial cell layer surrounding lobules of adipocytes. In the image, adipocytes are visualized using a staining against perilipin 1 , while mesothelial cells are stained using TM4SF1 and MSLN . DAPI staining was used to visualize cellular nuclei .
The study found that the mesenchymal-like properties of these cells are associated with an enhanced ability to modulate their microenvironment, providing a regulatory mechanism for limiting the expansion of adipose tissue. By switching between these two states, the cells may thus be able to influence the overall metabolic behavior of the omental fat depot and its capacity to accumulate fat without triggering metabolic complications.
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