Researchers Identify Potential Target for Treating Inner-Ear Bone Erosion

Researchers from Osaka University have identified activin A as a key factor in bone erosion caused by cholesteatomas, an abnormal cell growth in the ear, paving the way for potential new treatments beyond the current surgical options.

Figure 1. Schematic of osteoclastogenesis induced by cholesteatoma fibroblasts expressing activin A. Proinflammatory cytokines secreted from infiltrating macrophages induced activin A-expressing pathogenic fibroblasts; the activin A acted in conjunction with RANKL to promote ectopic osteoclastogenesis.

Figure 2. Subclustering and pseudotime analysis of human cholesteatoma fibroblasts. Cholesteatoma fibroblasts were associated with five subclusters labeled 1, 7, 8, 10, and 11 . The most differentiated cells were identical to cholesteatoma fibroblasts in subcluster 8 . Cholesteatoma fibroblasts showed high levels of INHBA expression, and the area of high INHBA expression was identical to the area in cholesteatoma fibroblasts in subcluster 8 .

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