University of Pittsburgh researchers have discovered markers in the blood that indicate biological age, developing an index that accurately differentiates between healthy and rapid aging. This could lead to early lifestyle interventions to improve long-term health.have identified blood-based markers that are associated with healthy and accelerated aging.
Healthy agers were 75 years or older and could ascend a flight of stairs or walk for 15 minutes without resting, and the rapid agers, who were 65 to 75 years old, had to rest during these challenges. “Other studies have looked at genetics to measure biological aging, but genes are very static: the genes you’re born with are the genes you die with,” said Gurkar. “We chose to look at metabolites because they are dynamic: They change in real-time to reflect our current health and how we feel, and we have the power to influence them through our lifestyles, diet, and environment.”
Using an artificial intelligence model that can predict potential drivers of biological traits, the team identified three main metabolites that were most likely to promote healthy aging or drive rapid aging. In future research, they plan to delve into how these metabolites and molecular pathways that produce them contribute to biological aging and explore interventions that could slow this process.
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