Although the specificity of CRISPR-based gene-editing is highly accurate and versatile, the efficiency of installing those edits has been low. In this paper, the Adamson lab describes a more efficient prime editor. Credit: Caitlin Sedwick for Princeton University
Authors Brittany Adamson, Assistant Professor of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics; and Jun Yan, Adamson lab graduate student and first author. Credit: Photo of Britt Adamson by Denise Applewhite, Princeton University. Photo of Jun Yan by the author. “Although promoting prime editing is obviously not a normal function of the La protein, our experiments showed that it can strongly facilitate the process,” Yan said.
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