Researchers have identified a crucial mechanism in which RNA methylation affects mitochondrial function, offering promising treatment prospects for neurological disorders and cancers. This breakthrough could lead to novel therapies by targeting mitochondrial dysfunction through RNA methylation.
The lab of Yongchao C. Ma, PhD, at Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago discovered a fundamental biological mechanism that could lead to new treatments for neurological diseases, such as spinal muscular atrophy and autism, as well as different cancers. The study was published in the journal regulates mitochondrial function. Mitochondria is best known for generating energy in the cell. However, Dr.
“Our finding establishes a critical link between RNA methylation, mitochondria, and diseases that relate to mitochondrial dysfunction, which means that now we have the potential for new treatments for many different disorders,” said Dr. Ma, who is the senior author on the study. He holds the Children’s Research Fund Endowed Professorship in Neurobiology at Lurie Children’s and is an Associate Professor of Pediatrics, Neurology, and Neuroscience atDr.
“We are very excited about this discovery and the promise of innovative treatments, which could involve developing modifiers of RNA methylation to rectify the mitochondrial defect,” said Dr. Ma. “We are also honored to contribute significantly to the study of RNA methylation. There is exponential growth in this field, and we hope that our ongoing research on RNA methylation in the nervous system will bring new insights into brain development and neurological disorders.
Reference: “m6A RNA methylation regulates mitochondrial function” by Michael Kahl, Zhaofa Xu, Saravanan Arumugam, Brittany Edens, Mariafausta Fischietti, Allen C Zhu, Leonidas C Platanias, Chuan He, Xiaoxi Zhuang and Yongchao C Ma, 14 March 2024,SciTechDaily: Home of the best science and technology news since 1998. Keep up with the latest scitech news via email or social media.
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