Scientists have collaborated to create the world’s first 3D-printed “brain phantom,” utilizing a special magnetic resonance imaging technique to model brain fibers. This advancement is aimed at improving research into neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis by enhancing the accuracy of dMRI analysis software through the use of these detailed brain models.
In order to further improve the process and test analysis and evaluation methods, an international team in collaboration with the Medical University of Vienna and TU Wien developed a so-called “brain phantom”, which was produced using a high-resolution 3D printing process.Researchers from the Medical University of Vienna as MRI experts and TU Wien as 3D printing experts worked closely with colleagues from the University of Zurich and the University Medical Centre Hamburg-Eppendorf.
This high-resolution method is primarily used to print microstructures in the nanometre and micrometer range – not for printing three-dimensional structures in the cubic millimeter range. In order to create phantoms of a suitable size for dMRI, the researchers at TU Wien have been working on scaling up the 3D printing process and enabling the printing of larger objects with high-resolution details.
In order to calibrate the analysis software, the brain phantom is therefore examined using dMRI, and the measured data is analyzed as in a real brain. Thanks to 3D printing, the design of the phantoms is precisely known and the results of the analysis can be checked. MedUni Vienna and TU Wien were able to show that this works as part of the joint research work.
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