A study by Nagoya University reveals that middle-age obesity may be caused by the shortening of specific brain structures that regulate metabolism, suggesting that dietary management could be key to prevention.and their colleagues in Japan have discovered that obesity in middle age is due to age-related alterations in the form of neurons in the hypothalamus, the brain region responsible for regulating metabolism and appetite.
“We believe that a similar mechanism exists in humans as well,” said Professor Kazuhiro Nakamura of theGraduate School of Medicine, the lead author of the study. “We hope our finding will lead to a fundamental treatment for obesity.” The researchers published the results of the study in the journalAs we get older, we become more prone to being overweight and obesity. Obese people are more susceptible to diabetes, hyperlipidemia, and other chronic diseases.
Shortening of MC4R+ primary cilia in the hypothalamus of the brain leads to middle-age obesity. Credit: Kazuhiro Nakamura The team also administered a hormone called leptin to the brains of rats with artificially shortened MC4Rcilia. Leptin is thought to help reduce food intake. Surprisingly, however, their appetite was not reduced, indicating that leptin could not exert anti-obesity effects.
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