Researchers have made a groundbreaking discovery about Long COVID’s neurological effects, including brain fog and cognitive decline. By identifying blood vessel disruption in the brain, they offer new insights for diagnosing and treating the condition, potentially transforming the approach to post-viral neurological syndromes. Credit: SciTechDaily.com
In the months after the emergence of the novel coronavirus SARS-CoV2 in late 2019 a patient-reported syndrome termed Long-COVID began to come to the fore as an enduring manifestation of acute infection.Long COVID has up to 200 reported symptoms to date, but in general, patients report lingering symptoms such as fatigue, shortness of breath, problems with memory and thinking, and joint/muscle pain.
“For the first time, we have been able to show that leaky blood vessels in the human brain, in tandem with a hyperactive immune system may be the key drivers of brain fog associated with Long COVID. This is critically important, as understanding the underlying cause of these conditions will allow us to develop targeted therapies for patients in the future,” said Prof. Matthew Campbell, Professor in Genetics and Head of Genetics at Trinity, and Principal Investigator at FutureNeuro.
Prof. Campbell added: “Here, the team at Trinity was able to prove that every patient that developed Long-COVID had been diagnosed with SARS-CoV2 infection, because Ireland required every documented case to be diagnosed using the more accurate PCR-based methods. The concept that many other viral infections that lead to post-viral syndromes might drive blood vessel leakage in the brain is potentially game-changing and is under active investigation by the team.
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