Scientists at Cambridge have found that fasting raises arachidonic acid levels in the blood, inhibiting inflammation and offering insights into the health benefits of fasting and the anti-inflammatory effects of drugs like aspirin on chronic diseases.
“What’s become apparent over recent years is that one inflammasome in particular – the NLRP3 inflammasome – is very important in a number of major diseases such as obesity and atherosclerosis, but also in diseases likeand Parkinson’s disease, many of the diseases of older age people, particularly in the Western world.”
When the researchers studied arachidonic acid’s effect in immune cells cultured in the lab, they found that it turns down the activity of the NLRP3 inflammasome.
“There could be a yin and yang effect going on here, whereby too much of the wrong thing is increasing your inflammasome activity and too little is decreasing it,” said Professor Bryant. “Arachidonic acid could be one way in which this is happening.”
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