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The World Health Organization has identified antimicrobial resistance as a worldwide concern because most clinical antibiotics are no longer effective against certain pathogenic bacteria. The Center for Antibiotic Discovery and Resistance at the. Bacteria can become resistant to antibiotics in a number of ways, including by developing efflux pumps – proteins that are located on the surface of the bacteria cell.
The inhibitors have a novel mechanism of action, which until recently remained unclear. Zgurskaya’s team, in collaboration with teams at the Georgia Institute of Technology and King’s College London in the United Kingdom, have uncovered that these inhibitors work as a “molecular wedge” that targets the area between the inner and outer cell membranes and increases antibacterial activities of antibiotics.
“We already live in a post-antibiotic era, and things will get much worse unless new solutions are found for antibiotic resistance in clinics. The discoveries we’ve made will facilitate the development of new treatments to help mitigate an impending crisis,” Zgurskaya said. Reference: “Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein” by Benjamin Russell Lewis, Muhammad R. Uddin, Mohammad Moniruzzaman, Katie M. Kuo, Anna J. Higgins, Laila M. N. Shah, Frank Sobott, Jerry M. Parks, Dietmar Hammerschmid, James C. Gumbart, Helen I.
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