and autism, researchers still do not understand how these mutations lead to brain developmental defects—and because of the uniqueness of human brain development, animal models are of limited use."Only a human model of the brain can recapitulate the complexity and particularities of the human brain," says IMBA Scientific Director Jürgen Knoblich, one of the study's corresponding authors.
"With this high-throughput methodology, we can systematically inactivate a list of disease-causing genes. As the organoids carrying these mutations grow, we analyze the effect of each mutation on the development of each cell type," says the study's first and co-corresponding author Chong Li, a postdoctoral fellow in the Knoblich group.
"Using this high-throughput single-cell expression data, we can quantify whether a given cell type is more or less abundant due to a given mutation, and we can also identify sets of genes that are commonly or distinctly affected by each mutation. By comparing across all the gene mutations, we can reconstruct the phenotypic landscape of these disease-linked genetic perturbations," explains Treutlein.
Technology Technology Latest News, Technology Technology Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Source: medical_xpress - 🏆 101. / 51 Read more »