AI predicts the effectiveness and evolution of gene promoter sequences

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A neural network can predict gene expression from promoter sequence.

Gene expression affects every aspect of life, from the survival of bacteria in specific environments to the anatomy and physiology of the human body.

The ability to accurately predict how strongly a gene is expressed on the basis of the DNA sequences that regulate such expression would transform how researchers study biology. But the biochemical machinery that regulates gene expression is tremendously complex, and this goal has eluded biologists’ best efforts for more than 50 years.

 

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