Researchers at UC San Diego have discovered that differences in autism severity are linked to brain development in the embryo, with larger brain organoids correlating with more severe autism symptoms. This insight into the biological basis of autism could lead to targeted therapies.
Brain cortical organoids created by Dr. Alysson Muotri shown in a 2019 file photo. Researchers at the University of California San Diego used stem cells from toddlers with autism and created BCOs from them. The stem cells of toddlers with autism developed into larger BCOs, they discovered. Toddlers with autism also had larger brain volumes, according to MRI. Credit: UC San Diego Health Sciences
“The bigger the brain, the better isn’t necessarily true,” agreed Alysson Muotri, Ph.D., director of the Sanford Stem Cell Institute’s Integrated Space Stem Cell Orbital Research Center at the university.
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